Immunogenic complex from N. gonorrhoeae

Details Immunogenic complex from N. gonorrhoeae Immunogenic complex from N. gonorrhoeae

1981-08-20

1983-05-31

Hazel, Blondel

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

424 88, 435253, 435 68, A61K 39095, C12P 2100, C12N 120

Patent

active

043860664

ABSTRACT:
A vesicular, immunogenic, non-pyrogenic complex is obtained from isolates of N. gonorrhoeae by cultivating N. gonorrhoeae on a suitable nutrient medium; harvesting and centrifuging the cells; extracting the cell pellet with TRITON X-100 at alkaline pH; suspending the solids remaining after extraction in aqueous medium and precipitating in the cold with ethanol.

REFERENCES:
patent: 4203971 (1980-05-01), Buchanan
patent: 4220638 (1980-09-01), Karkhanis et al.
Johnston et al., Intl. Symp. Gonorrhea, Ottawa, Canada, (1973).
Hill et al., Inf. And. Imm. 10, 605, (1974).
Frasch et al., J. Exp. Med., 147, 629 (1978).

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