Immunogenic anaplasma marginale surface antigens, compositions,

Details Immunogenic anaplasma marginale surface antigens, compositions, Immunogenic anaplasma marginale surface antigens, compositions,

1994-04-15

1996-08-27

Sidberry, Hazel F.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

4242651, 4242661, 4242701, A61K 3900, A61K 39002, A61K 39005, A61K 39018

Patent

active

055498981

ABSTRACT:
A purified antigenic surface protein of Anaplasma marginale has been identified, and is capable of inducing immune responses in ruminants which neutralizes virulent Anaplasma marginale. The antigenic surface protein has a molecular weight of about 105,000 daltons, and can be purified by an immunoaffinity chromatography process. The antigen has further utility in diagnostic tests for anaplasmosis. It can be synthesized by polypeptide procedures or by genetic engineering. DNA and amino acid sequences have been developed for the antigen according to this invention. The antigen is useful as a vaccine component for protecting mammals against infection by Anaplasma marginale and may be useful for rickettsial organisms other than Anaplasma marginale.

REFERENCES:
Palmer et al (1984) Immune Sera against Anaplasma Marginale initial bodis neutralizes infectivity for Cattle J & I.
Palmer et al (1985) Immunization with an Isolate-Common Surface Protein Protects Cattle Against Anaplasmosis Science.
Palmer et al Dec. 1985 Presence of Common Antigen including Major Surface Protein Epitopes, between the Cattle (Intraerythrocytic & Techstoges of Anaplasma Marginale.
Barbet et al 1983 Comparison of Proteins Synthesized by two different Isolates of Anaplasma Marginale.
Palmer et al, The Journal of Immunology, 1984 1010-15, Aug. Creceine Jul. 31, 1984).
Palmer, Dissertation Abst Internation, Jun. 1985 vol. 45 No. 7 p. #2069-B (Abstract Only).

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