Immunoenzymatic method in homogeneous phase for the determinatio

Details Immunoenzymatic method in homogeneous phase for the determinatio Immunoenzymatic method in homogeneous phase for the determinatio

1989-04-20

1993-05-11

Saunders, David

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 79, 435947, 435975, 436539, G01N 33539, G01N 33569

Patent

active

052100189

ABSTRACT:
An immunoenzymatic method for the detection of anti-Plasmodium falciparum-sporozoite antibodies in a sample of human blood, which operates, in homogeneous phase, and under suitable conditions, with a synthetic polypeptidic antigen (P), a synthetic antigen-enzyme (P-E) conjugate, wherein said antigen is capable of specifically reacting with the anti-Plasmodium falciparum-sporozoite antibodies (Ab) possibly present in the sample, and an inert substance capable of quantitatively precipitating the antibody-synthetic antigen-enzyme complex (Ab-P-E).
The method, due to its specificity, sensitivity, reproducibility and rapidity, is particularly useful in the epidemiological investigations into malaria and in the evaluation of the efficacy of an antimalarial vaccine.

REFERENCES:
patent: 4843146 (1989-06-01), Bernardi et al.
patent: 4855242 (1989-08-01), Soeldner
patent: 4977079 (1990-12-01), Nuzzolo et al.
G. Del Giudice et al, Journal of Clinical Micobiology, vol. 25, Jan. 1987, pp. 91-96.
F. Zavala et al, Journal of Immunological Methods, vol. 93, No. 1, Oct. 23, 1986, pp. 55-61.
Worthington Enzyme Manual, Worthington Biochemical Corporation, Freehold, N.J., 1972, pp. 43-45.

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