Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...
Patent
1995-06-06
1997-04-22
Nucker, Christine M.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Amino acid sequence disclosed in whole or in part; or...
4241841, 4241861, 4241851, 930220, 930221, 530326, 530826, A61K 3921
Patent
active
056227035
ABSTRACT:
The invention relates to peptides representing CTL epitopes from the HTLV-I envelope protein. The invention further relates to compositions, comprising the peptides, for priming a T-cell response in a subject. Furthermore, methods for priming a T-cell response by administration of the compositions to a subject and methods for evaluating the T-cell function of a patient are described.
REFERENCES:
patent: 4525300 (1985-06-01), Yoshida et al.
patent: 4663436 (1987-05-01), Elder et al.
patent: 4689398 (1987-08-01), Wu et al.
patent: 4724258 (1988-02-01), Yoshida et al.
patent: 4822606 (1989-04-01), Snyderman et al.
patent: 4833071 (1989-05-01), Wang et al.
patent: 4879212 (1989-11-01), Wang et al.
patent: 5017687 (1991-05-01), Vahlne et al.
patent: 5066579 (1991-11-01), Reyes
patent: 5476765 (1995-12-01), Wang
Tanaka et al., Journal of Immunology, vol. 147, No. 1, pp. 354-360 (1991).
Kiyokawa et al., Proc. Natl. Acad. Sci., USA, vol. 81, pp. 6202-6206 (1984).
Harlow et al., "Antibodies a Lab Manual", Cold Spring, Harbor, New York, pp. 130-132.
Atassi et al., "Antigen Specific T Cell Receptors and Factors," Ed. J.J. Machalonis, CRC press, Boca Roton, Florida, pp. 7-63.
Palker et al., "Mapping of Immunogen Regions of (HTLV-I) gp 46 and gp21 Envelope with env encoded synthetic peptide and monoclonal antibody to gp46," Journal of Immunology, vol. 142(3), pp. 971-978 (1989).
Malik et al., J. Gen. Vir., vol. 69, pp. 1695-1710 (1988).
Nakamur et al., Int. J. Cancer, vol. 40, pp. 403-407 (1987).
Gazzolo et al., "Direct Activation of Resting T Lymphocytes by Human T-lymphotrophic Virus Type I," Nature, vol. 326, pp. 714-717 (1987).
Harlow et al., "Antibodies: a Laboratory Manual," Cold Spring Harbor, New York, pp. 99 (1988).
Berzofsky Jay A.
Kurata Akihiko
Nucker Christine M.
Stucker Jeffrey
The United States of America as represented by the Department of
LandOfFree
Immunodominant sites of HTLV-I envelope protein does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Immunodominant sites of HTLV-I envelope protein, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Immunodominant sites of HTLV-I envelope protein will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-339804