Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1995-09-15
1998-10-20
Huff, Sheela
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
5303915, 5303917, 5303919, 514 12, 4241811, 4241791, 4241781, 435 697, 435 711, 536 234, A61K 3800, C07K 1600, C07K 1700, C07K 1714
Patent
active
058247823
ABSTRACT:
The invention provides new immunoconjugates comprising a mono-clonal antibody or a fragment thereof specific for the human EGF-receptor molecule and a member of the chemokine family, preferably selected from the C-X-C family, e.g. lnterleukin-8 (IL-8). The immunoconjugates induce cytotoxic and chemotactic activity and are suitable for a targeted tumor therapy.
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Baggiolini et al. J. Clin. Invest. 84:1045-1049, Oct. 1989.
Reisser et al. Anticancer Res. 14:977-980, Jun. 1994.
"Growth Factor Receptors as Targets for Antitumor Therapy with Monoclonal Antibodies," Waldmann et al., Monoclonal Antibody Therapy. Prog. Allergy, vol. 45, 1988, pp. 147-160.
Naramura et al., Chem. Abstract, vol. 120, No. 21, May 23, 1994.
Holzer Wolfgang
Matzku Siegfried
Strittmatter Wolfgang
von Hoegen Ilka
Huff Sheela
Merck Patent Gesellschaft mit beschrankter Haftung
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