Immunoconjugates and methods for their use in tumor therapy

Details Immunoconjugates and methods for their use in tumor therapy Immunoconjugates and methods for their use in tumor therapy

1990-08-07

1992-01-28

Russel, Jeffrey E.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

530391, 424 8591, C07K 1702, A61K 3944

Patent

active

050845608

ABSTRACT:
Novel pH-sensitive immunoconjugates which dissociate in low-pH tumor tissue, comprising a chemotherapeutic agent and an antibody reactive with a tumor-associated antigen are described. The chemotherapeutic agent is coupled to the antibody by a link which is unstable in low pH. The link may comprise a spacer consisting of a polyamino acid. Representative antibodies for use in these immunoconjugates include monoclonal antibodies which are not internalized by tumor cells.

REFERENCES:
patent: 4631190 (1986-12-01), Shen et al.
Blair et al (1983) J. Immunol. Methods 59: 129-143.
Gallego et al. (1984) Int. J. Cancer 33:737-744.
Jung et al. (1981) Biochem. Biophys. Res. Commun. 101(2):599-606.

Affiliated with

Also associated with

Rating

Immunoconjugates and methods for their use in tumor therapy does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Immunoconjugates and methods for their use in tumor therapy, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Immunoconjugates and methods for their use in tumor therapy will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1862119