Chemistry: analytical and immunological testing – Involving diffusion or migration of antigen or antibody
Patent
1991-08-30
1993-11-30
Nucker, Christine M.
Chemistry: analytical and immunological testing
Involving diffusion or migration of antigen or antibody
436501, 436518, 436524, 436528, 436531, 436534, 436533, 435 792, 435 793, 435 794, 435 795, 435805, 435970, 435969, G01N 33558, G01N 33566, G01N 33543, G01N 33551, G01N 33544, G01N 33545, G01N 33546, G01N 3353, C12Q 100
Patent
active
052664970
ABSTRACT:
An immunochromatography which comprises chromatographically moving a sample together with or followed by labelling fine particles in a chromatographic medium having at least one reaction site having immobilized thereat a reagent bindable to a substance to be detected in a sample, to contact the above sample and the labelling fine particles with the above reaction site, and detecting the substance to be detected by use of the phenomenon that when the above substance to be detected is present in the sample the labelling fine particles are specifically bound to the above immobilized reagent via the substance to be detected at the above reaction site, to thereby capture the substance to be detected on the chromatographic medium, characterized in that the above labelling fine particles are sensitized dyed particles obtained by sensitizing, with a material bindable to the above substance to be detected, labelling dyed particles obtained by dyeing latex particles of a synthetic high polymer, said labelling dyed particles having a surface negative charge of 0.01 to 0.5 meq/g. Said immunochromatography enables excellent visual judgement and detection of a substance to be detected which is present in a sample at a high sensitivity, and can be suitably used for the diagnosis of pregnancy.
REFERENCES:
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patent: 4916056 (1990-04-01), Brown, III et al.
patent: 5008080 (1991-04-01), Brown, III et al.
Brown (1987) Clin Chem 33:1567-1568.
Lim et al (1990) J Immunol Meth 135:9-14.
Imai Senzo
Kinoshita Masahiko
Kouda Yoshiko
Nishihara Toru
Japan Synthetic Rubber Co. Ltd.
Nucker Christine M.
Preston D. R.
Rohto Pharmaceutical Co. Ltd.
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