Chemistry: analytical and immunological testing – Involving diffusion or migration of antigen or antibody
Patent
1992-03-27
1995-03-28
Nucker, Christine M.
Chemistry: analytical and immunological testing
Involving diffusion or migration of antigen or antibody
422 57, 422 58, 422 56, 436530, 436521, 435 71, G01N 3350, G01N 33569, G01N 33544, G01N 33551
Patent
active
054016673
ABSTRACT:
A method for detecting the presence of a specific analyte in solution comprising the steps of affixing to a chromatographic medium a first antibody which binds with specificity to the analyte in a pattern which forms a pre-determined geometric symbol or symbols consisting of a plurality of line segments; partially blocking or obstructing the expected passage of a moving phase or solvent through the symbol; reacting the solution to a marker-second antibody complex which binds with specificity to the analyte to form analyte-marker-second antibody complexes in the presence of the analyte; eluting the solution containing any analyte-marker-second antibody complex through the partially blocked or obstructed medium; and observing the substantially complete formation, or lack thereof, of the predetermined geometric symbol or symbols by means of the marker.
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Cordell Ruffin B.
Dubrule Chris
Kile Bradford E.
McKeon Michael J.
Nucker Christine M.
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