Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Molecular bilayer structure
Patent
1978-02-24
1980-08-26
Fagelson, Anna P.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
Molecular bilayer structure
23230B, 424 9, 424 12, 424104, G01N 3350, G01N 3348, G01N 2726, G01N 2182
Patent
active
042195390
ABSTRACT:
Using anti-IgG and anti-Fc sera which is reacted with gastric cancer juice from a patient by double diffusion on Ouchterlony agarose, there is repeatedly obtained a double precipitin line. Under immunoelectrophoresis, anodic displacement of anti-IgG and anti-Fc sera is observed. The .beta..sub.1 to .alpha..sub.1 precipitin line with anti-IgG and anti-Fc is thus formed to be characteristic of gastric cancer juice. These double precipitin lines correspond to an antigen-antibody complex which are uniquely identified by Ouchterlony immunodiffusion assay with these anti-immunoglobulin sera. Only a single precipitin line is formed between gastric cancer juice and anti-Fab serum.
Both with anti-IgG and anti-Fc, various lines are obtained under immunoelectrophoresis with different mobilities, from gamma to .alpha..sub.1. With anti-Fab, however, there is no displacement toward the anode. Normally, Fc seldom moves beyond the site of origin. Thus, both IgG and Fc of gastric cancer juice exhibit a displacement toward the anode.
REFERENCES:
Piper (ed.), Stomach Cancer, UICC Tech. Report Series, vol. 34, Geneva, 1978, pp. 85-97.
Apffel et al., Cancer Res., vol. 33, Jan. 1973, p. 112.
Fagelson Anna P.
Saffitz Abraham A.
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