Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1994-05-20
1997-02-11
Scheiner, Toni R.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 792, 435 794, 435975, 436 63, 436 64, 436507, 436813, G01N 33574, G01N 3353, G01N 33537, G01N 33564
Patent
active
056019882
ABSTRACT:
This invention provides a specific immunocapture ELISA for the quantitation of cancer procoagulant antibody complex (CPAC) in biological samples. In particular, this invention provides methods and techniques for specifically selecting and quantitatively measuring CPAC from a sample material using anti-CP antibodies followed by labeled anti-immunoglobulin antibodies. The amount of captured CPAC is then determined by measuring the amount of label in the captured CPAC.
REFERENCES:
patent: 4711839 (1987-12-01), Singhal
patent: 4943524 (1990-07-01), Gordon
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Donati et al. (1986) "Cancer Procoagulant in Human Tumor Cells:Evidence from Melanoma Patients," Canc. Res. 46:6471-6474.
Gordon et al. (1990) "An Enzyme-linked Immunosorbent Assay for Cancer Procoagulant and Its Potential as a New Tumor Marker," Canc. Res. 50:6229-6234.
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Mielicki et al. (1990) "Cancer Procoagulant in Serum of Rats During Development of Experimental Epithelioma," Int. J. Cancer 45:125-126.
Kozwich et al. (1994) "The Clinical Utility of Cancer Procoagulant (CP) as an Early Stage Tumor Marker," ASCO Abstract ASCO Annual Meeting, Dallas, TX, May 14-17, 1994.
Eyler Yvonne
ImmunOnc, Inc.
Scheiner Toni R.
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