Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Matrices
Patent
1995-02-28
1997-08-12
Bawa, Raj
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Matrices
424488, 424489, 424469, A61K 914
Patent
active
056562985
ABSTRACT:
An immunobooster capable of delivering an immunogen to an individual or animal in a controlled release manner is described. The immunobooster contains an immunogen/hydrophobic polymer matrix with a swelling agent such that the swelling agent can swell in an aqueous environment and burst the matrix. The immunogen is released in a pulsed release manner after a desired time interval has elapsed subsequent to administration of the immunobooster. The immunobooster eliminates the need for multiple administrations of immunogen in order to build lasting immunity. Also described are methods of preparing and using the immunobooster, and kits containing the immunobooster.
REFERENCES:
patent: 3437728 (1969-04-01), Renwanz et al.
patent: 3599150 (1971-08-01), Fetaberg et al.
patent: 3743720 (1973-07-01), Fosker et al.
patent: 4242328 (1980-12-01), Hem et al.
patent: 4756907 (1988-07-01), Beck et al.
patent: 4784948 (1988-11-01), Scott et al.
patent: 4808404 (1989-02-01), Bhogal
patent: 4874613 (1989-10-01), Hsiao
patent: 4897268 (1990-01-01), Tice et al.
patent: 4919929 (1990-04-01), Beck
patent: 4921757 (1990-05-01), Wheatley et al.
patent: 4933185 (1990-06-01), Wheatley et al.
patent: 5008114 (1991-04-01), Lovrecich
patent: 5008116 (1991-04-01), Cahn
patent: 5026538 (1991-06-01), Lieberman et al.
patent: 5151273 (1992-09-01), Korsatko-Wabnegg et al.
Esparza I. et al., "Parameters Affecting the Immunogenicity of Microencapsulated Tetanus Toxoid", Vaccine, vol. 10, No. 10, (1992) pp. 714-720.
J. Freund, "The Effect of Paraffin Oil and Mycobacteria on Antibody Formation and Sensitization", Amer. Journal Clinical Pathology, 21(7), (1951) pp. 645-656.
M.R. Hilleman, "Immunologic, Chemotherapeutic and Interferon Approaches to Control of Viral Disease", American Journal of Medicine, vol. 38, (1965) pp. 751-766.
R. Langer et al., "Polymers for the sustained release of proteins and other macromolecules", Nature, vol. 263, (1976) pp. 797-800.
I. Preis eta l., "A Single-Step Immunization by Sustained Antigen Release", Journal of Immunological Methods, 28 (1979) pp. 193-197.
J. Kohn et al., "Single-step immunization using a controlled release, biodegradable polymer with sustained adjuvant activity", Journal of Immunological Methods, 95 (1986) pp. 31-38.
Crooker Stephen C.
Kitchell Judith P.
Bawa Raj
DynaGen, Inc.
LandOfFree
Immunobooster for delayed release of immunogen does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Immunobooster for delayed release of immunogen, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Immunobooster for delayed release of immunogen will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-158340