Chemistry: analytical and immunological testing – Involving production or treatment of antibody – Monoclonal antibody
Patent
1986-11-12
1989-08-22
Warden, Robert J.
Chemistry: analytical and immunological testing
Involving production or treatment of antibody
Monoclonal antibody
436 86, 435 7, 435 68, 4351722, 43524026, 43524027, 435243, 435948, 530331, 530345, 530387, 530806, 530808, 530809, 935 89, G01N 3353
Patent
active
048596132
ABSTRACT:
Monoclonal antibodies specifically immunologically reactive to thiol-modified glutathione and hybridoma cell lines producing such monoclonal antibodies. A method of producing antibodies specifically immunologically reactive with reduced glutathione by immunizing an animal using a thiol-modified glutathione, for example, a glutathione-N-ethylmaleimide-keyhole limpet hemocyanin conjugate. A method of utilizing the antibodies produced to quantitate the amount of reduced glutathione in a biological sample, to monitor glutathione-associated conditions, to monitor the formation of normal metabolic intermediates and to monitor the detoxification of foreign compounds.
REFERENCES:
patent: 4639420 (1987-01-01), Schaffner
A. Meister and M. E. Anderson, "Glutathione", Ann. Rev. Biochem. 52: 711-60 (1983).
E. Hayes et al., Measuring Leukotrienes of Slow Reacting Substance of Anaphylaxis: Development of a Specific Radioimmunoassay, The Journal of Immunology, 131, 492-433 (1983).
Warden Robert J.
Wieder Stephen C.
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