Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2005-09-13
2005-09-13
Harris, Alana M. (Department: 1642)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C530S387100, C530S387900, C530S388100, C530S388240, C530S388250, C436S501000, C436S063000, C435S007200, C435S007210, C435S007900, C435S345000
Reexamination Certificate
active
06942977
ABSTRACT:
Methods are described for the development of monoclonal antibodies to intrinsic factor and the application of said antibodies in the development of B12 immunoassays. In particular, antibodies are described that are capable of binding to intrinsic factor only in the absence of vitamin B12, and that are released from binding in the presence, and upon the binding, of vitamin B12 to intrinsic factor. Assays may be formatted such that either antibody or intrinsic factor is immobilized or labeled.
REFERENCES:
patent: 3505019 (1970-04-01), Axen et al.
patent: 4188189 (1980-02-01), Allen
patent: 4333918 (1982-06-01), Carney et al.
patent: 4351822 (1982-09-01), Allen
patent: 4355018 (1982-10-01), Hansen et al.
patent: 4418151 (1983-11-01), Forand et al.
patent: 4423154 (1983-12-01), Gutcho et al.
patent: 4426455 (1984-01-01), Tovey et al.
patent: 4447528 (1984-05-01), Ellis et al.
patent: 4451571 (1984-05-01), Allen
patent: 4465775 (1984-08-01), Houts
patent: 5310656 (1994-05-01), Pourfarzaneh et al.
patent: 9100519 (1991-01-01), None
Roitl et al.,Essential Immunology, Goner Medical Publ. 34-42 Cleveland St, London WIP5FB. pp. 7.1-7.6, 1989.
Samoloff, I. M. et al. Journal of Immunology, 101(3): 578-586, 1968.
W. Pfund, et al., The Conformation-Sensitive Immunoassay: A Membrane Based Elisa System for Identifying Antibodies Sensitive to Alteration of Protein Conformation:Molecular Immunology, 27:495-502 (1990).
J. Kolhouse, et al., “Cobalamin Analogues are Present in Human Plasr and Can Mask Cobalamin Deficiency Because Current RadioisotopeDilution Assays Are Not Specific For Tru Cobalamin, ”The New England Journal of Medicine, 299:785-792 (1970).
G. Garrido-Pinson, et al., “Studies of Human Intrinsic Factor Auto-Antibodies, ”Journal of Immunology, 97:897-912 (1966).
K. Taylor, “Inhibition of Intrinsic Factor by Pernicious Anaemia Sera, ” The Lancet, 2:106-108 (1959).
M. Schwartz, “Intrinsic Factor Antibody in Serum From Patients With Pernicious Anemia, ”The Lancet, 2:1263-1267 (1960).
I. Chen, et al., “Clinical Significance of Serum Vitamin B12 Measured by Radioassay Using Pure Intrinsic Factor, ”Clinical Sciences: Journal of Nuclear Medicine, 22:447-451 (1981).
Smokla, et al.,Gastroenterology, 98:607-614 (1990).
Galfre, et al.,Methods of Enzymology, 73:3-46 (1981).
Newman Karel
Schmidt Jane
Wegfahrt Paul
Bio-Rad Laboratories, Inc.
Harris Alana M.
Holleran Anne L.
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