Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1995-06-06
2000-02-29
Minnifield, Nita
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 736, 435 697, 435698, 4351723, 530300, 530350, G01N 33571, C12P 2104, C12N 1500, A61K 3800
Patent
active
060307994
ABSTRACT:
Methods and compositions are provided for the production of a polypeptide which is immunologically cross-reactive with a naturally-occurring major outer membrane protein (MOMP) of Chlamydia trachomatis. A DNA construct including a replication system recognized by E. coli, and an MOMP gene under the transcriptional control of a .beta.-glactosidase promoter and terminator is provided. Recombinant phage .lambda.gtll/L2/33 was deposited at the American Type Culture Collection, 12301 Parklawn Drive, Rockville, Md. 20852, on Jan. 10, 1985 and granted accession no. 40157. L2 B9-F DNA was deposited at the American Type Culture Collection on Dec. 31, 1985, and granted accession No. 40217.
REFERENCES:
patent: 4427782 (1984-01-01), Caldwell
patent: 4497899 (1985-02-01), Armstrong et al.
patent: 5770714 (1998-06-01), Agabian et al.
patent: 5821055 (1998-10-01), Agabian et al.
Wang et al., "Trachoma Vaccine Studies in Monkeys," Amer. J. Ophthal. 63:1615-1630 (1967).
Woolridge et al., "Long Term Follow-up of the Initial (1959-1960) Trachomas Vaccine Field Trial on Taiwan," Amer. J. Ophthal. 63:1645-1653 (1967).
Grayston and Wang, "New Knowledge of Chlamydiae and the Diseases They Cause," J. Infect. Dis. 132:87-105 (1975).
Caldwell et al., "Purification and Partial Characterization of the Major Outer Membrane Protein of Chlamydia trachomatis," Infect. Immun. 31:1161-1176 (1981).
Maniatis, et al., Molecular Cloning, The Cold Spring Harbor Lab, (1982).
Wenman et al., "Expression in E. coli of Chlamydia trachomatis Antigen Recognized During Human Infection," Nature, 296:68-70 (1982).
Stephens et al., "Monoclonal Antibodies to Chlamydia Trachomatis: Antibody Specificities and Antigen Characterization," J. Immunol. 128:1083-1089 (Mar., 1982).
Caldwell et al., "Neutralization of Chlamydia trachomatis Infectivity with Antibodies to the Major Outer Membrane Protein," Infect. Immun. 38:745-754 (1982).
Clark et al., Infect. Immun., 38:1273-1278 (1982).
Young, et al., "Efficient Isolation of Genes by Using Antibody Probes," Proc. Natl. Acad. Sci. USA, 80:1194-1198 (1983).
Allan et al., "Molecular Cloning of the Major Outer Membrane Protein of Chlamydia trachomatis," Infect. Immun. 45:637-641 (1984).
Nano et al., "Partial Amino Acid Sequence and Molecular Cloning of the Encoding Gene for the Major Outer Membrane Protein of Chlamydia trachomatis," Infect. Immun. 48:372-377 (1985).
Kaul et al., "Cloning and Expression in Escherichia coli of a Species-Specific Chlamydia trachomatis Outer Membrane Antigen," Chemical Abstracts, 103:151-152, Abst. No. 1544n (1985).
Stephens et al., "Molecular Cloning and Expression of Chlamydia trachomatis Major Outer Membrane Protein Antigens in Escherichia coli," Infect. Immun. 3:713-718 (1985).
Stephens et al., "Sequence Analysis of the Major Outer Membrane Protein Gene from Chlamydia trachomatis Serovar L.sub.2 ", J. Bacteriol., 168:1277-1282 (1986).
Ma, J. et al., "Identification of Conserved Regions for Species and Subspecies Specific Epitopes on the Major Outer Membrane Protein of Chlamydia trachomatis," Microb. Pathogenesis 3:299-307 (1987).
Pickett, M. A. et al., "Complete Nucleotide Sequence of the Major Outer Membrane Protein Gene from Chlamydia trachomatis Serovar L1," FEMS Microbiol. Lett., 42:185-90 (1987).
Stephens, R.S. et al., "Diversity of Chlamydia trachomatis Major Outer Membrane Protein Genes," J. Bacteriol. 169:3879-3885 (1987).
Stephens, R.S. et al., "High-Resolution Mapping of Serovar-Specific and Common Antigenic Determinants of the Major Outer Membrane Protein of Chlamydia trachomatis," J. Exp. Med., 167:817-831 (1988).
Stephens, R.S. "Chlamydial Genetics" in Microbiology of Chlamydia, (CRC Press, Boca Raton, FL, A. L. Barron, Ed.) 111-134 (1988).
Pickett, M.A. et al., "High-Level Expression and Epitope Localization of the Major Outer Membrane Protein of Chlamydia trachomatis serovar L1," Molec. Microbiol. 2:681-685 (1988).
Conlan et al., "Epitope Mapping with Solid-Phase Peptides: Identification of Type-, Subspecies-, Species- and Genus-reactive Antibody Binding Domains on the Major Outer Membrane Protein of Chlamydia trachomatis," Molec. Microbiol. 2:673-679 (1988).
Conlan et al., "Surface-exposed Epitopes on the Major Outer-membrane Protein of chlamydia trachomatis Defined with Peptide Antisera," J. Gen. Microbiol., 135:3219-3228 (1989).
Conlan et al., "Isolation of Recombinant Fragments of the Major Outer-Membrane Protein of Chlamydia Trachomatis: Their Potential as Subunit Vaccines," J. Gen. Microbiol., 136:2013-2020 (1990).
Hayes et al., "The Major Outer-Membrane Proteins of Chlamydia trachomatis Serovars A and B: Intra-Serovar Amino Acid Changes Do Not Alter Specificities of Serovar- and C Subspecies-Reactive Antibody-Binding Domains," J. Gen. Microbiol., 136:1559-1566 (1990).
Carter et al., "Nucleotide Sequence and taxonomic Value of the Major Outer Membrane Protein Gene of Chlamydia pneumoniae IOL-207," J. Gen. Microbiol., 137:465-475 (1991).
Dean, et al., "Direct Sequence Evaluation of the Major Outer Membrane Protein Gene Variant Regions of Chlamydia trachomatis Subtypes D', I' and L2'," Infect. Immun. 59:1579-1582 (1991).
Caldwell et al., "Immunoassay for Detecting Chlamydia trachomatis Major Outer Membrane Protein," J. of Clin. Microbiol. 18(3):539-545, Sep. 1983.
Caldwell et al., "Antigenic Analysis of the Major Outer Membrane Protein of Chlamydia spp.," Infect & Immun. 35(3): 1024-1031, Mar. 1982.
Caldwell et al., "Structural Analysis of Chlamydial Major Outer Membrane Proteins," Infect & Immun. 38(3): 960-968, Dec. 1982.
Collier, Lancet, 1:795-800 (1961), "Experiments with Trachoma Vaccines."
Goding, J.W., "Monoclonal Antibodies: Principles & Practice," (1983, Academic Press) pp. 180-181.
Agabian Nina
Kuo Cho-Chou
Mullenbach Guy
Stephens Richard
Baskar Padma
Minnifield Nita
Washington Research Foundation
LandOfFree
Immunoassays for detecting chlamydial antigens or antibodies the does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Immunoassays for detecting chlamydial antigens or antibodies the, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Immunoassays for detecting chlamydial antigens or antibodies the will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-681740