Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1993-12-30
1998-11-03
Scheiner, Laurie
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 79, 435 792, 435 793, 435 795, 435 7021, 435326, 435327, 435337, 5303871, 5303872, 5303881, 53038825, 436501, 436518, 436547, 436548, G01N 3353
Patent
active
058306811
ABSTRACT:
Monoclonal antibodies and fragments thereof, with binding specificity for an epitope on the carboxy terminus of prothrombin activation peptide F1.2, which can be used in immunoassays to predict thrombosis by measuring the extent of activation of prothrombin. These monoclonal antibodies are also included in a kit for performing such immunoassays.
REFERENCES:
patent: 5071954 (1991-12-01), Pelzer et al.
Pelzer, H. and Stuber, W., "Detection of Prothrombin Activation Fragments F.sub.2 /F.sub.1+2 by an Antibody Against a Synthetic Peptide," Haemostasis 1988, 18 Suppl. 2:Abstract #102.
Shi, Q. et al., "Detection of Prothrombin Activation with a Two-Site Enzyme Immunoassay for the Fragment F1.2," Thromb. Haemostas. 1989, 63:165, Abstract #493.
Davie, E.W. et al., "Cloning of Vitamin K-Dependent Clotting Factors," Dev. Biochem., 1983, vol. 25, Calcium-Binding, pp. 45-52.
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Butman Bryan T.
Dombrose Frederick A.
Hursting Marcie J.
Moore Bryant M.
Steiner Jerald P.
Akzo Nobel N.V.
Blackstone William M.
Gromley Mary E.
Muir Gregory R.
Scheiner Laurie
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