Chemistry: analytical and immunological testing – Involving immune complex formed in liquid phase – Separation of immune complex from unbound antigen or antibody
Patent
1981-09-15
1983-06-07
Marantz, Sidney
Chemistry: analytical and immunological testing
Involving immune complex formed in liquid phase
Separation of immune complex from unbound antigen or antibody
436517, 436519, 436520, 436813, 436814, 436817, 436818, 436826, G01N 3354
Patent
active
043871666
ABSTRACT:
The sensitivity of hemagglutination inhibition tests is improved by introducing a determined amount of lyophilized antigen or antibody into serological tubes in the absence of the indicator component. The test fluid to be analyzed is incubated solely in the presence of its binding partner in a liquid phase. After completion of the binding reaction (about 5 hours but extendable to 18 hours), the sensitized indicator solid phase, usually consisting of sensitized red blood cells, is added. By this process a 10 to 20 fold increase in sensitivity of the hemagglutination inhibition test is routinely achieved.
REFERENCES:
patent: 3887697 (1975-06-01), Vyas
patent: 4205954 (1980-06-01), Babson
patent: 4308026 (1981-12-01), Mochida
"Methods in Enzymology", S. P. Colowick et al., eds., vol. 70, entitled Immunochemical Techniques, H. Van Vunakis et al., eds., pp. 462, 463, contributed by F. L. Adler et al., Academic Press, New York, 1980.
Chemical Abstracts, 81:87587r, (1974).
Anda Biologicals
Daniel William J.
Marantz Sidney
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