Immunoassay using optical interference detection

Details Immunoassay using optical interference detection Immunoassay using optical interference detection

1984-06-25

1987-03-03

Nucker, Christine M.

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

436519, 436527, 436528, 436531, 436805, 436807, 436909, 356317, 356318, 2504611, G01N 3354, G01J 330

Patent

active

046475443

ABSTRACT:
Apparatus and method for providing an optical detection of a binding reaction between a ligand and an antiligand, including, a pattern formed by a spatial array of microscopic dimensions of antiligand material, ligand material interacting with the antiligand material to produce a binding reaction between the ligand and the antiligand in the pattern, a source of optical radiation including energy at at least one wavelength directed to the pattern at a particular incidence angle to produce scattering of the energy from the pattern in accordance with the binding reaction and with a strong scattering intensity at one or more Bragg scattering angles, and at least one optical detector located relative to the pattern and aligned with a Bragg scattering angle to detect the strong scattering intensity at the Bragg scattering angle to produce a signal representative of the binding reaction.

REFERENCES:
patent: 4487839 (1984-12-01), Kamentsky
patent: 4521522 (1985-06-01), Lundstrom et al.
patent: 4537861 (1985-08-01), Elings et al.

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