Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1987-07-13
1991-04-30
Nucker, Christine
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
2504611, 356244, 356317, 356318, 356354, 422 55, 422 8205, 435 721, 435970, 436518, 436519, 436524, 436527, 436528, 436531, 436541, 436805, 436807, 436909, C01N 3353
Patent
active
RE0335819
ABSTRACT:
Apparatus and method for providing an optical detection of a binding reaction between a ligand and an antiligand, including, a pattern formed by a spatial array of microscopic dimensions of antiligand material, ligand material interacting with the antiligand material to produce a binding reaction between the ligand and the antiligand in the pattern, a source of optical radiation including energy at at least one wavelength directed to the pattern at a particular incidence angle to produce scattering of the energy from the pattern in accordance with the binding reaction and with a strong scattering intensity at one or more Bragg scattering angles, and at least one optical detector located relative to the pattern and aligned with a Bragg scattering angle to detect the strong scattering intensity at the Bragg scattering angle to produce a signal representative of the binding reaction.
REFERENCES:
patent: 4487839 (1984-12-01), Kamentsky
patent: 4521522 (1985-06-01), Lundstrom et al.
patent: 4537861 (1985-08-01), Elings et al.
Elings Virgil B.
Nicoli David F.
Nucker Christine
Terlizzi Laura
Walker William B.
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