Chemistry: analytical and immunological testing – Involving kinetic measurement of antigen-antibody reaction
Patent
1995-03-17
1999-12-28
MacMillan, Keith D.
Chemistry: analytical and immunological testing
Involving kinetic measurement of antigen-antibody reaction
436518, 436527, 436531, 436800, 436805, 435 4, 435 71, 435 793, 435 794, 435973, G01N 33557, G01N 33543, G01N 3353
Patent
active
060080574
ABSTRACT:
Disclosed is a method of assaying, in assay apparatus, for at least the ligand intended to be used to assay analyte in a sample, with which analyte the ligand will specifically bind. The method provides a product in which a ligand is labeled with a detectable tag and is immobilized on an appropriate substrate. An assay is made to measure the immobilized, labeled ligand by detecting the tag labeling the latter. The product can then be used to assay for the analyte by contacting the latter so as to form a complex. The extent and rate of specific binding of the analyte in the complex is identifiable, either by competition assay or sandwich assay as a rate of change, so the relative proportions of analyte and ligand are readily determinable.
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Block Myron J.
Glass Thomas R.
MacMillan Keith D.
Ponnaluri P.
Roche Diagnostics Corporation
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