Chemistry: analytical and immunological testing – Involving immune complex formed in liquid phase – Signal modification or steric inhibition
Patent
1995-05-04
1998-05-12
Ceperley, Mary E.
Chemistry: analytical and immunological testing
Involving immune complex formed in liquid phase
Signal modification or steric inhibition
436546, 436815, G01N 33536
Patent
active
057504130
ABSTRACT:
Cyclosporine derivatives useful as detectable tracer compounds for the immunoassay determination of cyclosporine are disclosed. The cyclosporine derivatives comprise a detectable moiety coupled to the amino acid at the first position (MeBmt) in cyclosporine, the second position (Abu) in cyclosporine, the third position (Sar) in cyclosporine, the eighth position (D-Ala) in cyclosporine, or the tenth position (MeLeu) in cyclosporine. A preferred cyclosporine derivative comprises a fluorescent moiety coupled to the hydroxyl group of the amino acid at the first position in cyclosporine, and is especially useful for the fluorescent polarization immunoassay determination of cyclosporine. A fluorescent polarization immunoassay method and test kit are also disclosed.
REFERENCES:
patent: 4727035 (1988-02-01), Mahoney
patent: 5169773 (1992-12-01), Rosenthaler et al.
patent: 5427960 (1995-06-01), Wang et al.
Lunetta Steven E.
Meucci Victoria P.
Morrison Marjorie A.
Simpson Elizabeth A.
Zajac Mariola B.
Abbott Laboratories
Ceperley Mary E.
Levis John F.
LandOfFree
Immunoassay reagents and method for determining cyclosporine does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Immunoassay reagents and method for determining cyclosporine, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Immunoassay reagents and method for determining cyclosporine will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-978574