Immunoassay of thyroxine in neonates using dried blood samples

Details Immunoassay of thyroxine in neonates using dried blood samples Immunoassay of thyroxine in neonates using dried blood samples

1978-11-29

1981-11-10

Padgett, Benjamin R.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Molecular bilayer structure

23230B, 424 12, 435 4, 435 7, G01N 3348, G01T 100

Patent

active

042998123

ABSTRACT:
In the immunoassay of thyroxine using dried blood samples spotted on filter paper, the assay in this invention is run at a pH of 9.2 to 10.0, preferably at about 9.5, rather than the pH range of about 8.4 to 8.7 generally used in the art. The advantage of this higher pH range is that more accurate results are obtained with neonatal specimens. An additional advantage is that the blank or nonspecific binding is lower for many immunoassay procedures.

REFERENCES:
patent: 3716632 (1973-02-01), Fader et al.
patent: 3745211 (1973-07-01), Brown et al.
patent: 3928553 (1975-12-01), Hollander

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