Chemistry: analytical and immunological testing – Involving producing or treating antigen or hapten
Patent
1981-11-06
1984-06-19
Padgett, Benjamin R.
Chemistry: analytical and immunological testing
Involving producing or treating antigen or hapten
436512, 436513, 436518, 436528, 436534, 436825, G01N 3368
Patent
active
044553811
ABSTRACT:
In the immunoassay of a particular protein in a biological fluid, there is frequently interference in the assay by other proteins present in the fluid, e.g. by complement factors or antibodies in human serum. The interference so caused can be avoided by subjecting the fluid to protein-digestion, using for example an enzyme such as pepsin, as a result of which the particular protein of interest, or a fragment thereof, can be assayed without interference by the other proteins. Also, radioallergosorbent tests for particular IgE antibodies can be improved in sensitivity and accuracy, by subjecting the absorbed IgE to enzymic digestion, and then assaying a fragment thereof.
REFERENCES:
Bluard-Deconink et al., Biochemical Journal, vol. 171, pp. 321-327, (1978).
Bluard-Deconink et al., J. Clinical Endocrinology Metabolism, vol. 42, pp. 189ff, (1976).
Collet-Cassart Daniel
Magnusson Carl-Gustaf M.
Masson Pierre L.
International Institute of Cellular and Molecular Pathology
Moskowitz M.
Padgett Benjamin R.
Tedesco S. P.
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