Chemistry: analytical and immunological testing – Involving immune complex formed in liquid phase
Patent
1982-02-02
1983-06-14
Marantz, Sidney
Chemistry: analytical and immunological testing
Involving immune complex formed in liquid phase
436 63, 436 71, 436543, 436547, 436811, 436815, G01N 3354, G01N 3392
Patent
active
043884121
ABSTRACT:
An immunologic assay for determining the presence of one or more phospholipids in a biological fluid. The method includes adding an ethanolic solution of diacylphosphatidylcholine or alkyltrimethylammonium halide and cholesterol to the biological fluid forming a macromolecular aggregate complex solution. To this solution is added antibody molecules to the phospholipids in an aqueous buffered medium causing an agglutination reaction. The product of the reaction is then examined to determine the presence of the phospholipids.
The method is particularly useful in determining the presence of phosphatidylglycerol in a sample of amniotic fluid. Thus, the assay may be used in evaluating fetal lung maturity.
REFERENCES:
patent: 4233032 (1980-11-01), Statland
patent: 4257771 (1981-03-01), Yee
patent: 4290772 (1981-09-01), Frey
patent: 4292041 (1981-09-01), Fullerton
D. E. Freer et al., Clin. Chem., 27(10), 1629-1641, (1981).
Chemical Abstracts, 92:142867m (1980).
Chemical Abstracts, 93:128400t (1980).
Chemical Abstracts, 93:112185r and 112186s (1980).
Hana Biologics, Inc.
Marantz Sidney
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