Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Attached to antibody or antibody fragment or immunoglobulin;...
Patent
1975-02-10
1976-10-26
Padgett, Benjamin R.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
Attached to antibody or antibody fragment or immunoglobulin;...
260112R, 424 88, G01N 3300, A61K 3900
Patent
active
039884309
ABSTRACT:
The preparation of antigens and their selective antibodies for antipyrine therefrom as well as an immunoassay for antipyrine using said antibodies is described. Such radioimmunoassay can be utilized to determine an individual's antipyrine half-life which has been correlated with the genetically controlled level of benzo[a]pyrene hydroxylase induction. The latter measurement has been associated with risk to bronchogenic carcinoma. Thus determination of the antipyrine half-life by means of the instant radioimmunoassay can be used as a screening test for identifying individuals at special risk to lung cancer.
REFERENCES:
patent: 3709868 (1973-01-01), Spector
banerjee et al., Chemical Abstracts, vol. 71, No. 7, Aug. 18, 1969, Abstract No. 27443Z.
Dixon William Ross
Wood Alexander
Gould George M.
Hoffmann-La Roche Inc.
Nucker Christine M.
Padgett Benjamin R.
Welt Samuel L.
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