Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals
Patent
1983-01-05
1984-12-11
Nucker, Christine M.
Chemistry: analytical and immunological testing
Involving an insoluble carrier for immobilizing immunochemicals
436524, 436528, 436537, 436541, 436542, 436800, 436804, 436807, 436808, 436809, 436823, G01N 3352, G01N 3358
Patent
active
044878397
ABSTRACT:
Methods for determining the presence of antigens or antibodies in an aqueous sample or presence of antigens on the surface of cells. A preferred embodiment employs fluorescent antigens which compete with the sample antigens for antibody binding sites. The antibodies are deposited on a support surface means in alternating patterns. The surface means and fluorescence detector are translocated with respect to each other and a signal generated by the detection of the repeating pattern of fluorescence. The signal is analyzed by means of a gated integrator responsive to a gate track control means also located on the surface means. Immunoassay methods having increased sensitivity are thereby obtained.
REFERENCES:
patent: 3941876 (1976-03-01), Marinkovich
patent: 4011308 (1977-03-01), Giaever
patent: 4031197 (1977-06-01), Marinkovich
Walden, Diss. Abstracts B, vol. 41 (1980), pp. 561-562.
Deeloer et al., Chem. Abstracts, vol. 90 (1979) #68828q.
Hofer Mark A.
Nucker Christine M.
Ortho Diagnostic Systems Inc.
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