Immunoassay method and analyzer using magnetic particles

Details Immunoassay method and analyzer using magnetic particles Immunoassay method and analyzer using magnetic particles

1997-07-17

1999-11-30

Ludlow, Jan

Chemical apparatus and process disinfecting, deodorizing, preser

Analyzer, structured indicator, or manipulative laboratory...

Chemiluminescent

209215, 209217, 210222, 210695, 422101, 435 792, 4352872, 4352887, 436526, 436538, 436824, G01N 33553

Patent

active

059937408

ABSTRACT:
Magnetic particles are used as the solid phase to carry out immunoassay. In a reaction vessel, the magnetic particles are mixed with a sample containing TSH as an analyte and a labeled antibody. A chemiluminescent label material is bound onto the magnetic particles with an immunoreaction. A fluid including the above mixture is introduced to a chamber inside a flow through cell, the chamber being sized to have a width greater than a depth. The magnetic particles in the fluid are trapped by a magnet so as to be spread in the planar form over a predetermined area within the chamber, while useless materials are discharged outwardly of the chamber. The chamber is then filled with a buffer solution containing an attractant. By applying a voltage to electrodes disposed in the chamber, the label material on the magnetic particles is excited to emit an electro-chemiluminescence. The luminescence is detected by a photomultiplier.

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patent: 5240863 (1993-08-01), Shibue et al.
patent: 5466416 (1995-11-01), Ghaed et al.
patent: 5536475 (1996-07-01), Moubayed et al.
patent: 5541072 (1996-07-01), Wang et al.
patent: 5705402 (1998-01-01), Leland et al.

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