Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Attached to antibody or antibody fragment or immunoglobulin;...
Patent
1974-09-05
1976-07-20
Sebastian, Leland A.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
Attached to antibody or antibody fragment or immunoglobulin;...
23230B, 232306, G01N 3100, G01T 116
Patent
active
039707466
ABSTRACT:
An immunoassay for the measurement of total thyroxine in blood serum which employs trichloracetic acid and base to precipitate or denature the protein to quantitatively extract thyroxine. This procedure along with the use of radioactively labeled T.sub.4 antiserum, and the resin sponge to separate free and bound hormone, minimizes the number of steps required in the assay, which can be performed in the same tube in less than ninety minutes.
REFERENCES:
patent: 3206602 (1965-09-01), Eberle
Murphy et al., Journal of Clinical Endocrinology, vol. 24, Feb., 1964, pp. 187-196.
Mitchell et al., Journal of Clinical Endoerinology, vol. 20, Nov. 1960, pp. 1474-1483.
Sterling et al., Journal of Clinical Endocrinology, vol. 21, Apr. 1961, pp. 456-464.
Fato Gildo E.
Niblack Robert L.
Nucker Christine M.
Premachandra Bhartur
Sebastian Leland A.
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