Immunoassay for the detection of MIA

Details Immunoassay for the detection of MIA Immunoassay for the detection of MIA

1997-12-18

1999-10-26

Hutzell, Paula K.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

5303873, 5303871, 5303877, 5303881, 5303888, 53038885, 436547, 435 71, 435 721, 435 723, 435 79, 435 793, 435 794, 435 701, 4351722, C07K 1618, C07K 1624, G01N 3353, G01N 33536

Patent

active

059731230

ABSTRACT:
The subject matter of the present invention are high-affinity monoclonal antibodies against MIA (Melanoma inhibitory activity) in native conformation, which can be used for the detection of malignant melanomas, their use for the detection of MIA as well as immunoassays for the detection of MIA.

REFERENCES:
patent: 5770366 (1998-06-01), Bogdahn et al.
CA 125:237905, 1995.
Harlow and Lane, Antibodies, A Lab manual, pp. 27-28, 1988.
Blesch et al., Proceedings of the American Association for Cancer Research, vol. 35, Mar. 1994, p. 567, "Expression and function of a novel, potent malignant melanoma cell . . . ".
Bosserhoff et al., Cancer Research, vol. 57, No. 15, Aug. 1, 1997, pp. 3149-3153, "Melanoma-inhibiting activity, a novel serum marker for progression of malignant melanoma."
Hau et al., Proceedings of the American Association for Cancer Research, vol. 38, Mar. 1997, "Evidence for an alternative splice product of MIA/CD-RAP."

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