Immunoassay for pyridostigmine

Details Immunoassay for pyridostigmine Immunoassay for pyridostigmine

1989-04-10

1993-12-07

Wax, Robert A.

Chemistry: analytical and immunological testing

Involving immune complex formed in liquid phase

Separation of immune complex from unbound antigen or antibody

436543, 436545, 436547, 436804, 424 88, 5303898, G01N 33531, G01N 33534, G01N 3353, A61K 3514

Patent

active

052683087

ABSTRACT:
A radioimmunoassay for pyridostigmine in biological fluids. The method disclosed can detect 250 pg of pyridostigmine per ml of biological fluid using 0.1 ml of biological fluid. The antibody used in this method is raised from an antigen produced by diazotizing para-aminobenzoic acid and reacting the diazotized material with pyridostigmine to form a pyridostigmine-hapten solution, which is then reacted with bovine serum albumen. The antibody used in the disclosed method has a cross-reactivity with the major metabolites of pyridostigmine of less than 2%.

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