Immunoassay for measurement of reticulocytes, and immunoreactive

Details Immunoassay for measurement of reticulocytes, and immunoreactive Immunoassay for measurement of reticulocytes, and immunoreactive

1982-03-09

1984-05-08

Nucker, Christine M.

Chemistry: analytical and immunological testing

Involving producing or treating antigen or hapten

436544, 436545, 436546, 436547, G01N 3354, G01N 3358, G01N 3360

Patent

active

044475470

ABSTRACT:
The reticulocyte content present in a specimen of red blood cells is quantitatively measured based upon the selective immunoreactivity of the reticulocyte portion of the specimen with a reticulocyte-specific antibody which is immunoreactive with proteinaceous material associated with reticulocytes but not associated with mature red blood cells. Such immunoreactive proteinaceous material may be transferrin, transferrin receptor, transcobalamin II, or transcobalamin II receptor. Various procedures are described for quantitating such selective immunoreactivity, including fluorescent and radioactive detection techniques employing direct or indirect fluorescent or radioactive labeling of the reticulocyte-specific antibody.

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patent: 4273757 (1981-06-01), Selhub et al.
Seligman et al., J. Biol. Chem., 254(1979): 9943-9946.
Trowbridge et al., Proc. Natl. Acad. Sci.: USA, 78(1981): 3039-3043.
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Trowbridge et al., Nature, 294(1981) 171-173.
Enns et al., J. Biol. Chem., 256(1981): 12620-12623.
Steiner, J. Lab. Clin. Med., 96(1980): 1086-1093.

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