Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1989-10-16
1992-12-22
Kepplinger, Esther L.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435806, 436518, 436811, 436815, 436817, G01N 3353, G01N 33543
Patent
active
051734044
ABSTRACT:
A protein having a molecular weight of from about 10,000 to 18,000 daltons, isoelectric points of from about pH 4.0 to 6.5 and having the reversible biological effect of inhibiting aromatase activity in a biological system, and antibodies to the protein, modulate follicular development and spermatogenesis and provide for diagnostic tests of gonadel functions.
REFERENCES:
DiZerega et al., "Identification of Protein(s) Secreted by the Preovulatory Ovary Which Suppresses the Follicle Response to Gonadotropins", J. Clin. Endocrin. Metab. vol. 54, No. 6, pp. 1091-1096.
DiZerega et al., "Human Granulosa Cell Secretion of Protein(s) Which Suppress the Follicle Response to Gonkdotropins", J. Clin. Endocrin. Metabl, vol. 56, No. 1, pp. 147-155.
Di Zerega et al., "Identification of Proteins in Pooled Human Follicular Fluid Which Suppresses Follicular Response to Gonadotropins", J. Clin. Endocrin, Metab., vol. 56, No. 1, pp. 35-41.
Battin et al., "Effect of Human Menopausal Gonadotropin and Follicle Regulatory Protein(s) on 3.beta.-Hydroxysteroid Dehydrogenase in Human Granulosa Cells", J. Clin. Endocrin. Metab., vol. 60, No. 6, pp. 1116-1119.
Kepplinger Esther L.
University of Southern California
Wolski Susan C.
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