Immunoassay for biologically active human interferon-gamma emplo

Details Immunoassay for biologically active human interferon-gamma emplo Immunoassay for biologically active human interferon-gamma emplo

1984-01-13

1987-05-19

Marantz, Sidney

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

436536, 436548, 436531, 436541, 436808, 435 68, 4351722, 435240, 935108, 935110, 530351, G01N 3354

Patent

active

046668659

ABSTRACT:
Rapid, sensitive and accurate immunoassays for biologically active natural or recombinant human interferon-gamma (huIFN-gamma) based upon monoclonal antibodies which react specifically with epitopes of the biologically active form of huIFN-gamma are disclosed. The immunoassays include sandwich immunoradiometric assay of the forward, reverse or simultaneous type and competitive binding assay such as radioimmunoassay. The assays are also useful for the detection of macrophage activation factor now believed to be identical to huIFN-gamma. In addition, methods of purification of huIFN-gamma employing the monoclonal antibodies are described.

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patent: 4423147 (1983-12-01), Secher
patent: 4474892 (1984-10-01), Murad et al.
patent: 4514507 (1985-04-01), Secher
Kohler and Milstein, Nature, 256, 495 (1975).
Oleszak et al, Hybridoma, 2(4) pp. 439-449, (1983).
Hochkeppel, H. K. and M. deLey (1982), Nature 296, 258-259.
Rubin, B. Y. et al., (1983) J. Immunol. 130, 1019.
Novick, D. et al., (1983) The Embo J. 2, 1527-1530.

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