Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1984-02-17
1988-12-06
Marantz, Sidney
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
424 858, 435810, 436518, 436531, 436534, 436548, 530387, 530413, G01N 3353, G01N 33545, G01N 33569
Patent
active
047896310
ABSTRACT:
A serum antibody assay for assaying a serum sample is described which has diagnostic value for determining the presence of a specific serum antibody which may be indicative of an infection by a specific microorganism. The serum antibody assay has an enhanced diagnostic value because it can eliminate interference by selected cross-reactive antibodies which are directed against one or more other microorganisms to which the assay is not directed and which may be present in the serum sample with a clinically significant frequency. The serum antibody assay uses an immunologically purified fraction of antigenic material derived from the specific microorganism to which assay is directed. The immunologically purified fraction of antigenic material includes immunologically distinguishable components of the antigenic material. These immunologically distinguishable components are reactive with the antibodies to be assayed and are nonreactive with certain antibodies not to be assayed, even where these certain antibodies not to be assayed are cross-reactive with antigen from the microorganism to be diagnosed. The immunologically distinguishable components are made using an immunoadsorption method. The immunoadsorption method may be specially screened monoclonal antibodies which bind only the immunologically distinguishable components. Alternatively, the immunoadsorption method may use polyclonal antibodies which bind immunologically cross-reactive components and leave the immunologically distinguishable components unbound.
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Lewis Donald G.
Marantz Sidney
Synbiotics Corporation
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