Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals
Patent
1991-03-27
1994-01-25
Saunders, David
Chemistry: analytical and immunological testing
Involving an insoluble carrier for immobilizing immunochemicals
204400, 204403, 204409, 204415, 422 57, 422 58, 422 8201, 422 8202, 435 79, 435 793, 435288, 435291, 435817, 436524, 436525, 436806, 436807, G01N 2708, G01N 27327, G01N 23553
Patent
active
052815390
ABSTRACT:
A device and process for detecting the presence of organic molecular analytes in a fluid comprising a first binding component having a predetermined first affinity for specifically reversibly binding an analyte, a molecular conjugate of the analyte with a signal generating molecule that generates a detectable signal, and a second binding component having a predetermined second affinity for reversibly binding the signal generating molecule. In the presence of analyte, a fluid conducting system allows competitive binding of the analyte with the molecular conjugate and causes displacement of the conjugate and conducts the displaced conjugate to the second binding component. The signal generating molecule generates a detectable signal distinguishing binding thereof at the first or second binding components thereby indicating the presence of the analyte in the fluid.
REFERENCES:
patent: 4228237 (1980-10-01), Hevey et al.
patent: 4277560 (1981-07-01), Gray et al.
patent: 4803170 (1989-02-01), Stanton et al.
patent: 4868108 (1992-09-01), Bahar et al.
patent: 5124253 (1992-06-01), Foulds et al.
Chin Christopher L.
Saunders David
The Regents of the University of Michigan
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