Immunoassay comprising a truncated pneumococcal surface protein

Details Immunoassay comprising a truncated pneumococcal surface protein Immunoassay comprising a truncated pneumococcal surface protein

1995-06-06

1999-02-16

Caputa, Anthony C.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 71, 435 732, 435885, 4242441, 4241921, 42419711, 530350, 530402, 530403, 436518, 436524, 436531, G01N 33569, G01N 33543, C07K 14315, C07K 1700

Patent

active

058719431

ABSTRACT:
A purified pneumococcal surface protein A (PspA) comprises a truncated form of the PspA protein which is immunoprotective and contains the protective epitopes of PspA. The PspA protein is soluble in physiologic solution and lacks at least the cell membrane anchor region of the whole protein. The protein is formed by insertion-duplication of mutagenesis of S. pneumoniae with pspA gene and expression of the truncated protein into the growth medium.

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