Immunoassay and monoclonal antibodies for urinary cortisol

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

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5303881, 5303891, 5303898, 5303899, 435 71, 435975, 436547, 436548, C07K 1600

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059105755

ABSTRACT:
A polyclonal or monoclonal antibody recognizing specifically cortisol in a urine medium produced by immunization of animals against an immunogen compound composed of the hapten cortisol-3-carboxymethyloxime (syn isomer), coupled by its carboxyl function to a macromolecule, an immunoasay process for cortisol, particularly urinary cortisol, an assay kit and novel derivatives of coritsol.

REFERENCES:
patent: 4339390 (1982-07-01), Ali et al.
patent: 4366143 (1982-12-01), Midgley et al.
Philomin et al., "New Applications of Carbonylmetalloimmunoassay (CMIA): A Non-Radioisotopic Approach to Cortisol Assay," Journal of Immunological Methods, 171:201-210, 1994.
Norbert W. Tietz (ed), Textbook of Clinical Chemistry (WB Saunders Company--Philadelphia), p. 1073, 1986.
Hampl et al, Recent Advances in Immunoassay of Steroid Hormones, TRAC vol. 8, No. 2, pp. 72-75, Feb. 1989.

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