Immunoassay

Details Immunoassay Immunoassay

2008-03-25

2008-03-25

Gabel, Gailene R. (Department: 1641)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C435S007100, C435S007920, C435S962000, C435S967000, C435S973000, C436S518000, C436S524000, C436S528000, C436S540000, C436S546000, C436S548000, C436S172000, C436S175000, C530S403000

Reexamination Certificate

active

10819213

ABSTRACT:
A method for detection and/or quantification of cardiac troponin I (cTnI) in a sample derived from an individual's blood, the method being based on a sandwich immunoassay employing at least two capture antibodies and at least one tracer antibody, in which a first capture antibody is directed to the N-terminal part of cTnI, to the C-terminal part of cTnI or to the part of the cTnI midfragment, which is slightly affected by the interfering factor, and a second capture antibody is directed to another of these parts, and a tracer antibody is directed to the N-terminal part of cTnI, to the C-terminal part of cTnI or to TnC, which is complexed with cTnI.

REFERENCES:
patent: 6114180 (2000-09-01), Doth et al.
patent: WO 97/49994 (1997-12-01), None
patent: WO 99/64868 (1999-12-01), None
Katrukha et al., Degradation of cardiac troponin I: implication for reliable immunodetection, Clinical Chemistry 44 (12): 2433-2440.
Oh et al., Use of a Dual Monoclonal Sold Phase and a Polyclonal Detector to Create an Immunoassay for the Detection of Human Cardiac Troponin I, Clinical Biochemistry 33: 255-260 (Jun. 2000).
Eric Davies et al., “Analytical Performance and Clinical Utility of a Sensitive Immunoassay for Determination of Human Cardiac Troponin I”,Clinical Biochemistry30:6, 479-490 (1997).
Gaelle Ferrieres et al., “Human Cardiac Troponin I: Precise Identification of Antigenic Epitopes and Prediction of Secondary Structure”,Clinical Chemistry44:3, 487-493 (1998).
Susann Eriksson et al., “Nagative Interference in Cardiac Troponin I Immunoassays from a Frequently Occurring Serum and Plasma Component”,Clinical Chemistry49:7, 1095-1104 (2003).
Se-Kyung Oh et al., “Use of a Dual Monoclonal Solid Phase and a Polyclonal Detector to Create and Immunoassay for the Detection of Human Cardiac Troponin I”,Clinical Biochemistry33:4, 255-263 (2000).
Giuliani et al., “Determination of Cardiac Troponin I Forms in the Blood of Patients with Acute Myocardial Infarction and Patients Receiving Crystalloid or Cold Blood Cardioplegia,” 45Clin.Chem.212-222 (1999).
Katrukha et al., “Troponin I is Released in Bloodstream of Patients with Acute Myocardial Infarction Not in Free Form but as Complex,” 43Clin.Chem.1379-1385 (1997).
Bohner et al., “False-Negative Immunoassay Results for Cardiac Troponin I Probably Due to Circulating Troponin I Antibodies,” 42Clin.Chem.2046 (1996).

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