Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1983-07-19
1986-07-15
Warden, Robert J.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
436517, 436804, G01N 3353, G01N 33557, G01N 33534
Patent
active
046006907
ABSTRACT:
There is disclosed a method for immunoassay and/or competitive binding assay, wherein an excess amount of unlabeled antigen is added after the start of the reaction between the labeled ligand, the unlabeled ligand, and the binding agent or antibody, to saturate or flood the antibody binding sites. This provides increased sensitivity allowing for more reliable and precise measurements of ligands including antigens than heretofore. The present method extends the scope of applicability of competitive binding technique for assay of hormones, drugs and other compounds.
REFERENCES:
patent: 3899298 (1975-08-01), Szczesniak
patent: 4134792 (1979-01-01), Boguslaski et al.
patent: 4492751 (1985-01-01), Boguslaski et al.
Radioimmunoassay of Biologically Active Compounds, Parker, Prentice-Hall Inc., New Jersey, 1976, pp. 130-133.
Karmen Arthur
Lasky Fred D.
Albert Einstein College of Medicine of Yeshiva University, A div
Warden Robert J.
White Patricia Kate
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