Immunoaffinity purification methods using single polypeptide cha

Details Immunoaffinity purification methods using single polypeptide cha Immunoaffinity purification methods using single polypeptide cha

1995-06-06

1996-07-09

Budens, Robert D.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Separation or purification

5303873, 4241351, 435 696, 435 7021, 4351722, 4351723, 4352402, 43524027, 4353201, 43525233, 536 2353, C07K 122, C07K 1600

Patent

active

055346219

ABSTRACT:
The invention pertains to a single polypeptide chain binding molecule which has binding specificity and affinity substantially similar to the binding specificity and affinity of the light and heavy chain aggregate variable region of an antibody, to genetic sequences coding therefor, and to recombinant DNA methods of producing such molecule and uses for such molecule.

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Goldenberg et al., "Cancer Diagnosis and Therapy With Radiolabeled Antibodies," in Immunoconjugates, Antibody Conjugates in Radioimaging and Therapy of Cancer, pp. 259-280, 1987.
Vitetta et al., Science, 219:644, 1983.
Pastan et al., Cell 47:641, 1986.

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