Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof
Patent
1995-01-30
1999-04-27
Hutzell, Paula K.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Monoclonal antibody or fragment thereof
435332, 4353431, 4241521, 5303882, 5303887, 53038873, C07K 1628, C12N 512, A61K 39395
Patent
active
058978623
ABSTRACT:
A monoclonal antibody having immuno-stimulatory effects, binds specifically to B lymphoblastoid cells and induces proliferation and activation of peripheral blood lymphocytes, and when injected into tumor-bearing animals elicts an anti-tumor effect.
REFERENCES:
patent: 5182368 (1993-01-01), Ledbetter
Osband and Ross, Immunology Today 11: 193-195 1990.
Hoskins et al., Cancer Immunol Immunother 29:226-230, 1989.
Brown et al, Blood 73: 651-661, 1989.
Hird and Epenetos, Ch 17 "Immunotherapy with Monoclonal Antibodies" in Genes and Cancer, Ed by Carney & Sikora, 1990 John Wiley & Sons, pp. 183-189.
Clark, Edward A. et al., "Amplification of the Immune Response by Agonistic Antibodies," Immunology Today, vol. 7, No. 9, 1986.
Meuer, Stefan C. et al., "Triggering of the T3-Ti Antigen-Receptor Complex Results in Clonal T-cell Proliferation Through an Interleukin 2-Dependent Autocrine Pathway," Proc. Natl. Acad. Sci. USA, vol. 81, pp. 1509-1513, Mar. 1984.
Van Wauwe, Jean P. et al., "OKT3: A Monoclonal Anti-Human T Lymphocyte Antibody With Potent Mitogenic Properties," The Journal of Immunology, vol. 124, No. 6, Jun. 1980.
Jung, Gundram et al., "Induction of Cytotoxicity in Human Peripheral Blood Mononuclear Cells by Monoclonal Antibody OKT3" The Journal of Immunology, vol. 139, No. 2, pp. 639-644, Jul. 15, 1987.
Van Lier, R. et al., "Studies on the Monocyte Dependence of T-Cell Proliferation Induced by Monoclonal Antibodies Directed Against Regions I and II of the CD2 Antigen," Immunology, vol. 67, pp. 333-338, 1989.
Ellenhorn, Joshua D. et al., "In Vivo Administration of Anti-CD3 Prevents Malignant Progressor Tumor Growth," Science (Washington, D.C.), vol. 242, pp. 569-571, Oct. 1988.
Gallinger, Steven et al., "Comparison of Cellular Immunotherapies and Anti-CD3 in the Treatment of MCA-38-LD Experimental Hepatic Metastases in C57BL/6 Mice," Cancer Research, vol. 50, pp. 2476-2480, 1990.
Ledbetter, Jeffrey A. et al., "Antibodies to Tp67 and Tp44 Augment and Sustain Proliferative Responses of Activated T Cells," The Journal of Immunology, vol. 135, No. 4, 2331-2336, Oct. 4, 1985.
Moretta, Alessandro et al., "CD69-mediated Pathway of Lymphocyte Activation: Anti-CD69 Monoclonal Antibodies Trigger the Cytolytic Activity of Different Lymphoid Effector Cells with the Exception of Cytolytic T Lymphocytes Expressing T Cell Receptor .alpha./ .beta.," J. Exp. Med., vol. 174, pp. 1393-1398, Dec. 1991.
Van Lier, Renee A. W. et al., "Signals Involved in T Cell Activation. T Cell Proliferation Induced Through the Synergistic Action of Anti-CD28 and Anti-CD2 Monoclonal Antibodies," Eur. J. Immunol, vol. 18, pp. 167-172, 1988.
Jenkins, Marc K. et al., "CD28 Delivers A Costimulatory Signal Involved In Antigen-Specific IL-2 Production by Human T. Cells," The Journal of Immunology, vol. 147, No. 8, pp. 2461-2466, Oct. 15, 1991.
Townsend, Sarah E. et al., "Tumor Rejection After Direct Costimulation of CD8.sup.+ T Cells By B7-Transfected Melanoma Cells," Science (Washington, D.C.), vol. 259, pp. 368-370, Jan. 15, 1993.
Hardy, Britta et al., "A Monoclonal Antibody to Human B Lymphoblastoid Cells Activates Human and Murine T Lymphocytes," Cellular Immunology, vol. 118, pp. 22-29, 1989.
Hardy, Britta et al., "A Monoclonal Antibody Against a Human B Lymphoblastoid Cell Line Induces Tumor Regression in Mice," Cancer Research, vol. 54, pp. 5793-5796, Nov. 15,1994.
Hardy Britta
Novogrodsky Avraham
Choung Suet M.
Hutzell Paula K.
Johnson Nancy A.
Mor Research Applications Ltd.
Nath Gary M.
LandOfFree
Immuno-stimulatory monoclonal antibodies does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Immuno-stimulatory monoclonal antibodies, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Immuno-stimulatory monoclonal antibodies will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-684664