Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Chemical modification or the reaction product thereof – e.g.,...
Patent
1993-10-29
1998-03-10
Budens, Robert D.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Chemical modification or the reaction product thereof, e.g.,...
4241851, 4242691, 435 693, 435 697, 4351723, 530350, 530395, 530402, 530404, C07K 1107, C12P 2102
Patent
active
057262926
ABSTRACT:
The invention is directed to improved immunopotentiating systems for preparation of immunogenic materials. More particularly, the invention is directed to immunogenic compositions containing a protein, polypeptide, or peptide, a hydrophobic anchor, and a proteosome. The immunogenic compositions are suitable for use as therapeutic agents and vaccines.
REFERENCES:
Lowell et al., "Proteosome-Lippeptide Vaccines: Enhancement of Immunogenicity for Malaria CS Peptides," Science 240:800-802, 6 May 1988.
Fahey et al., "Status of Immune-based Therapies in HIV Infection and AIDS," Clin. Exp. Immunol. 88:1-5, 1992.
Fox, J.L., "No Winners Against AIDS," Biol Technology 12:128, Feb. 1994.
Lowell et al. "Peptides to Proteosomes Via Hydrophobic Feet Become Highly Immunogenic Without Adjuvants," J. Exp. Med. 167:658-663, Feb. 1988.
Smith et al., "The Role of Lauroyl and Cys-Tyr-Gly-Gly In T Cell Activation by Synthetic Peptides From Aasmdium falcipariana Circumsporozoite Protein," Technological Advances in Vaccine Development, Alan R. Liss, Pub., pp. 651-659,1988.
W. Arraham et al., "Construction of a Synthetic Anti-HIV Vaccine: Role of the Nature of Carrier and Peptide Presentation," VII Int'l Conf on AIDS, Florence, Italy, Abstract No TH.A.67, Jun. 1991.
Yang et al; "Identification and Characterization of Host-Protective T Cell Epitopes of a Major Surface Exoprotein(gpb3) from Leishmanin major," Immunology 72:3-9, 1991.
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