Drug – bio-affecting and body treating compositions – Extract or material containing or obtained from a...
Reexamination Certificate
2006-11-14
2006-11-14
Tate, Christopher R (Department: 1655)
Drug, bio-affecting and body treating compositions
Extract or material containing or obtained from a...
C424S400000, C424S439000, C424S442000
Reexamination Certificate
active
07135183
ABSTRACT:
The present invention provides medicinally active extracts and fractions, and a method for preparing the same by extracting and fractioning constituents from the tissue of plant components ofGanoderma lucidum. These active extracts and fractions are useful for inhibiting tumor growth, modulating immune response, and increasing hematopoietic activity.
REFERENCES:
Chung et al. (Anti Neoplastic components of Korean Basidomycetes, Korean Journal of Mycology (1980) vol. 8, No. 2, pp. 107-114).
Mizuno et al. (Fractionation chemical modification and antitumor activity of water-insoluble polysaccharides of the fruit-body ofGanoderma-lucidum, Nippon Nogeidagaku Kaishi, (1985) vol. 59, No. 11, pp. 1143-1152).
T. Mosmann, “Rapid Colorimetric Assay for Cellular Growth and Survival: Application to Proliferation and Cytotoxicity Assays”, Journal of Immunological Method; 65 (1983) 55-63.
Y. Sone, et al., “Structures and Antitumor Activities of the Polysaccharides Isolated from Fruiting Body and the Growing Culture of Mycelium ofGanoderma lucidum”, Agric. Biol. Chem., 49 (9) 2461-2653, 1985.
T. Usui, et al., “Isolation and Characterization of Antitumor Active β-D-Glucans from the Fruit Bodies ofGanoderma applanatum”, Carbohydrate Research, 115 (1983) 273-280.
T. Miyazaki, et al., “Structural Examination of an Alkali-Extracted, Water-Soluble Heteroglycan of the FungusGanoderma lucidum”, Carbohydrate Research, 109 (1982) 290-294.
B. L. Somani, et al., “A Modified Antrone-Sulfuric Acid Method for the Determination of Fructose in the Presence of Certain Proteins”, Analytical Biochemistry, 167, 327-330 (1987).
M. A. Jermyn, “Increasing the Sensitivity of the Anthrone Method for Carbohydrate”, Analytical Biochemistry, 68, 332-335 (1975).
M. N. Halhoul, et al., “Differential Determination of Glucose and Fructose, and Glucose- and Fructose- Yielding Substances with Anthrone”, Analytical Biochemistry, 50, 337-343 (1972).
R. Bowden, et al., “Alteration of cytokine levels in Murine Retrovirus Infection: Modulation by Combination Therapy”, International Journal of Immunopharmacology 21, (1999) 815-827.
E. Murphy, et al., “Detection of in vivo Expression of Interleukin-10 Using a Semi-Quantifative Polymerase Chain Reaction Method inSchistosoma mansoniInfected Mice”, Journal of Immunological Methods, 162 (1993) 211-223.
D. H. Spackman, et al., “Automatic Recording Apparatus for Use in the Chromatography of Amino Acids”, Analytical Chemistry, vol. 30, No. 7, Jul. 1958, 1190-1206.
C. H. Lo et al., Simple Fractionation of Phospholipase A2Analogues from Snake Venom by High-Performance Liquid Chromatography., Journal of Chromatography, 530 (1990) 129-136.
G. Franz, “Polysaccharides in Pharmacy: Current Applications and Future Concepts”, Planta Medica 55 (1989) 493-497.
E. Furusawa, et al., “Antitumor Activity ofGanoderma lucidum, an Edible Mushroom, on Intraperitoneally Implanted Lewis Lung Carcinoma in Synergenic Mice”, Phytotherapy Research, vol. 6, 300-304 (1992).
J. C. Sanchez, et al., “The Mouse SWISS-2D Page database: A Tool for Proteomics Study of Diabetes and Obesity”, Proteomics 2001, 1, 136-163.
S. Y. Wang, et al., “The Anti-Tumor Effect ofGanoderma lucidumis Mediated by Cytokines Released From Activated Macrophages and T Lymphocytes”, Int. J. Cancer: 70, 699-705 (1997).
V. V{hacek over (e)}tvi{hacek over (c)}ka, et al., “Soluble β-Glucan Polysaccharide Binding to the Lectin Site of Neutrophil or Natural Killer Cell Complement Receptor Type 3 (CD11b/CD18) Generates a Primed State of Receptor Capable of Mediating Cytotoxicity of iC3b-Opsonized Target Cells”, The American Society for Clinical Investigation, Inc., vol. 98, No. 1, Jul. 1996, 50-61.
J. A. G. Van Stijp, et al., Ligand Specificity of Purified Complement Receptor Type Three (CD11b/CD18, αmβ2, Mac-1), The Journal of Immunology, vol. 151, 3324-3336, No. 2, Sep. 15, 1993.
Antje Müller, et al., “Receptor Binding and Internalization of a Water-Soluble (1→3)-β-D-Glucan Biologic Response Modifier in Two Monocyte/Macrophage Cell Lines”, The Journal of Immunology, 1996, 156: 3418-3425.
Y. Y. Wang, et al. , “Studies on the Immuno-Modulating and Antitumor Activities ofGanoderma lucidum(Reishi) Polysaccharides: Functional and Proteomic Analyses of a Fucose-Containing Glycoprotein Fraction Responsible for the Activities”, Bioorganic & Medicinal Chemistry 10 (2002) 1057-1062.
Chen Hong-Sen
Chen Shui-Tein
Khoo Kay-Hooi
Lin Chun-Cheng
Lin Chun-Hung
Academia Sinica
Greenberg & Traurig, LLP
Tate Christopher R
Winston Randall
LandOfFree
Immuno-modulating antitumor activities of Ganoderma lucidum... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Immuno-modulating antitumor activities of Ganoderma lucidum..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Immuno-modulating antitumor activities of Ganoderma lucidum... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3706620