Immuno-modulating antitumor activities of ganoderma lucidum...

Drug – bio-affecting and body treating compositions – Extract or material containing or obtained from a...

Reexamination Certificate

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C424S400000, C424S439000, C424S442000

Reexamination Certificate

active

07323176

ABSTRACT:
The present invention provides medicinally active extracts and fractions, and a method for preparing the same by extracting and fractioning constituents from the tissue of components ofGanoderma lucidum. These active extracts and fractions are useful for inhibiting tumor growth, modulating immune response, and increasing hematopoietic activity.

REFERENCES:
patent: 5334704 (1994-08-01), Tsunoo et al.
patent: 6395310 (2002-05-01), Iwasaki
patent: 6464982 (2002-10-01), Lam
patent: 6613754 (2003-09-01), Wu
Chung et al., (Anti Neoplastic Components of Korean Balsidomycetes, Korean Journal of Mycology (1980) vol. 8, No. 2, pp. 107-114.
Mizuno et al., Fractionation Chemical Modification and Antitumor Activity of Water-Insoluble Polysaccharides of the Fruit-body of Ganoderma-Lucidum, Nippon Nogeidagaku Kaishi, (1985) vol. 58, No. 11, pp. 1143-1152.
T. Mosman, “Rapid Colorimetric Assay for Cellular Growth and Survival: Application to Proliferation and Cytotoxicity Assays”, Journal of Immunological Methods: 65 (1983) pp. 55-63.
Y. Sone, et al., “Structures and Antitumor Activities of the Polysaccharides Isolated from Fruiting Body and the Growing Culture of Mycelium of Ganoderma Lucidum”, Agric. Biol. Chem., 49 (9) (1985) pp. 2461-2653.
T. Usui, et al., “Isolation and Characterization of Antitumor Active β-D-Glucans from the Fruit Bodies of Ganoderma applanatum”, Carbohydrate Research, 115 (1983) pp. 273-294.
T. Miyazaki, et al., “Structural Examination of an Alkali-Extracted, Water-Soluble Heteroglycan of the Fungus Ganoderma Lucidum”, Carbohydrate Research, 109 (1982), pp. 290-294.
B. L. Somani, et al., “A Modified Antrone-Sulfuric Acid Method for the Determination of Fructose in the Presence of Certain Proteins”, Analytical Biochemistry, 167, (1987), pp. 327-330.
M. A. Jermyn, “Increasing the Sensitivity of the Anthrone Method for Carbohydrate”, Analytical Biochemistry, 68, (1975), pp. 332-335.
M. N. Halhoul, et al., “Differential Determination of Glucose and Fructose, and Glucose- and Fructose- Yielding Substances with Anthrone”, Analytical Biochemistry, 50, (1972), pp. 337-343.
R. Bowden, et al., “Alteration of Cytokine Levels in Murine Retrovirus Infection: Modulation by Combination Therapy”, International Journal of Immunopharmacology 21 (1999), pp. 815-827.
E. Murphy, et al., “Detection of in vivo Expression of Interleukin-10 Using a Semi-Quantifative Polymerase Chain Reaction Method in Schistosoma Mansoni Infected Mice”, Journal of Immunological Methods, 162 (1993), pp. 211-223.
D. H. Spackman, et al., “Automatic Recording Apparatus for Use in the Chromatography of Amino Acids”, Analytical Chemistry, vol. 30, No. 7, (Jul. 1958), pp. 1190-1206.
C. H. Lo et al., Simple Fractionation of Phospholipase A2Analogues from Snake Venom by High-Performance Liquid Chromatography, Journal of Chromatography, 530, (1990), pp. 129-136.
G. Franz, “Polysaccharides in Pharmacy: Current Applications and Future Concepts”, Planta Medica, 55, (1989), pp. 493-497.
E. Furusawa, et al., “Antitumor Activity of Ganoderma Lucidum, an Edible Mushroom, on Intraperitoneally Implanted Lewis Lung Carcinoma in Synergenic Mice”, Phytotherapy Research, vol. 6, (1992), pp. 300-304.
J. C. Sanchez, et al., The Mouse Swiss-2D Page database: A Tool for Proteomics Study of Diabetes and Obesity:, Proteomics, 1, (2001), pp. 136-163.
S. Y. Wang, et al., “The Anti-Tumor Effect of Ganoderma Lucidum is Mediated by Cytokines Released from Activated Macrophages and T Lymphocytes”, Int. J. Cancer. 70, (1997), pp. 699-705.
V. V{hacek over (e)}tvi{hacek over (c)}ka, et al., Soluble β-Glucan Polysaccharide Binding to the Lectin Site of Neutrophil or Natural Killer Cell Complement Receptor Type 3 (CD11b/CD18) Generates a Primed State of Receptor Capable of Mediating Cytotoxicity of iC3b-Opsonized Target Cells, The American Society for Clinical Investigation, Inc., vol. 98, No. 1, (Jul. 1996), pp. 50-61.
J. A. G. Van Strijp, et al., Ligand Specificity of Purified Complement Receptor Type Three (CD11b/CD18, αmβ2, Mac-1), The Journal of Immunology, vol. 151, No. 2, (Sep. 15, 1993), pp. 3324-3336.
Antje Müller, et al., “Receptor Binding and Internalization of a Water-Soluble (1-3-β-D-Glucan Biologic Response Modifier In Two Monocyte/Macrophage Cell Lines”, The Journal of Immunology, 156, (1996), pp. 3418-3425.
Y. Y. Wang, et al., Studies on the Immuno-Modulating and Antitumor Activities of Ganoderma Lucidum (Reishi) Polysaccharides: Functional and Proteomic Analyses of a Fucose-Containing Glycoprotein Fraction Responsible for the Activities:, Bioorganic & Medicinal Chemistry 10 (2002) pp. 1057-1062.
Courtesy copy of International Search Report, PCT/US05/36961 dtd. Jun. 27, 2006.
Courtesy copy of International Search Report, PCT/US06/37028, dtd. Mar. 22, 2007.

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