Immunizing and anti-infectious adjuvant agents constituted by N-

Details Immunizing and anti-infectious adjuvant agents constituted by N- Immunizing and anti-infectious adjuvant agents constituted by N-

1977-03-07

1979-05-08

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Lymphokine

2601125R, 424177, 424 92, A61K 3702, C07C10352

Patent

active

041536843

ABSTRACT:
The invention relates to new water-soluble agents which are effective as immunizing adjuvants. These adjuvant agents are the methyl, ethyl or propyl esters of 2-(2-acetamido-2-deoxy-3-O-D-glucopyranosyl)-D-propionyl-L-alanyl-D-isoglu tamine and of 2-(2-acetamido-2-deoxy-3-O-D-glucopyranosyl)-D-propionyl-L-alanyl-D-glutam ic acid, the 2-(2-acetamido-2-deoxy-3-O-D-glucopyranosyl)-D-propionyl-L-alanyl-D-(.alph a.-methylamide)-glutamic and 2-(2-acetamido-2-deoxy-3-O-D-glucopyranosyl)-D-propionyl-L-seryl-D-isoglut amine, the 2-(2-acetamido-2-deoxy-3-O-D-glucopyranosyl)-D-propionyl-L-seryl-D-glutami c acid and their derivatives. They are particularly useful to prepare adjuvant medicinal compositions, used for increasing the efficiency of vaccines.

REFERENCES:
Kotani, et al., Biken Journal 18, 105-111 (1975).

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