Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Virus or component thereof
Reexamination Certificate
2005-05-10
2005-05-10
Salimi, Ali R. (Department: 1648)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Virus or component thereof
C424S184100, C435S006120
Reexamination Certificate
active
06890538
ABSTRACT:
The invention relates to a vaccine against herpes simplex virus (HSV) comprising an invasive but attenuated or non-pathogenic bacterium, which bacterium comprises a coding sequence encoding a HSV antigen in a form that enables said coding sequence to be transferred to a host cell of a human or animal host which the bacterium is capable of invading and to be expressed in said cell to form said antigen without the introduction of an antimicrobial agent to lyse the bacterium. The invention also provides similar vaccines against other viruses.
REFERENCES:
patent: 5877159 (1999-03-01), Powell et al.
patent: 6150170 (2000-11-01), Powell et al.
patent: WO 9634631 (1996-11-01), None
patent: WO 9844131 (1998-10-01), None
patent: WO 9918221 (1999-04-01), None
Flo et al. Vaccine, 2001, vol. 19, pp. 1772-1782.*
Medina et al , Vaccine, 2000, vol. 19, pp. 1573-1580.*
Fennelly et al, “Mucosal DNA Vaccine Immunization Against Measles with a Highly AttenuatedShigella flexneriVector”, The Journal of Immunology 162:1603-1610 (1999).
Karem et al, “Protective Immunity Against Herpes Simplex Virus (HSV) Type 1 Following Oral Administration of RecombinantSalmonella TyphimuriumVaccine Strains Expression HSV Antigens”, Journal of General Virology 78:427-434 (1997).
Okada et al, “Intranasal Immunization of a DNA Vaccine with IL-12- and Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)-Expressing Plasmids in Liposomes Induces Strong Mucosal and Cell-Mediated Immune Responses Against HIV-1 Antigens”, Journal of Immunology 157(7):3638-3647 (1997).
Kuklin et al, “Role of Mucosal Immunity in Herpes Simplex Virus Infection”, The Journal of Immunology 160:5998-6003 (1998).
Paglia et al, “Gene Transfer in Dendritic Cells, Induced by Oral DNA Vaccination WithSalmonella typhimurium, Results in Protective Immunity Against a Murine Fibrosarcoma”, Blood 92:3172-3176 (1998).
Darji et al, “Oral Somatic Transgene Vaccination Using Attenuated S. typhimurium”, Cell 91:765-775 (1997).
Kuklin et al, “Induction of Mucosal Immunity against Herpes Simplex Virus by Plasmid DNA Immunization”, Journal of Virology 71(4):3138-3145 (1997).
Bourne et al, “DNA Immunization against Experimental Genital Herpes Simplex Virus Infection”, The Journal of Infectious Diseases 173:800-807 (1996).
Bourne et al, “DNA immunization confers protective immunity on mice challenged intravaginally with herpes simplex virus type 2”, Vaccine 14(13):1230-1234 (1996).
Sizemore et al, “AttenuatedShigellaas a DNA Delivery Vehicle for DNA-Mediated Immunization”, Science 270:299-302 (1995).
Bernstein and Stanberry, “Herpes simplex virus vaccines”, Vaccine 17:1681-1689 (1999).
Chabalgoity et al, “ASalmonella typhimurium htrAlive vaccine expressing multiple copies of a peptide comprising amino acids 8-23 of herpes simplex virus glycoprotein D as a genetic fusion to tetanus toxin fragment C protects mice from herpes simplex virus infection”, Molecular Microbiology 19(4):791-801 (1996).
Manickan et al, “Genetic Immunization Against Herpes Simplex Virus—Protection Is Mediated by CD4+ T Lymphocytes”, The Journal of Immunology 155:259-265 (1995).
McClements et al, “Immunization with DNA vaccines encoding glycoprotein D or glycoprotein B, alone or in combination, induces protective immunity in animal models of herpes simplex virus-2 disease”, Proc. Natl. Acad. Sci. USA 93:11414-11420 (1996).
McDermott et al, “T Lymphocytes in Genital Lymph Nodes Protect Mice from Intravaginal Infection with Herpes Simplex Virus Type 2”, The Journal of Infectious Diseases 159(3):460-466 (1989).
McClements et al, “The prophylactic effect of immunization with DNA encoding herpes simplex virus glycoproteins on HSV-induced disease in guinea pigs”, Vaccine 15(8):857-860 (1997).
Gallichan and Rosenthal, “Specific secretory immune responses in the female genital tract following intranasal immunization with a recombinant adenovirus expressing glycoprotein B of herpes simplex virus”, Vaccine 13(16):1589-1595 (1995).
Baralle Francisco
Flo Juan
Tisminetzky Sergio
International Centre for Genetic Engineering and Biotechnology
Nixon & Vanderhye P.C.
Salimi Ali R.
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