Immunization against Group B streptococci

Details Immunization against Group B streptococci Immunization against Group B streptococci

1981-10-29

1983-01-04

Hazel, Blondel

Drug, bio-affecting and body treating compositions

Lymphokine

424 85, 424 92, A61K 3940, A61K 39395

Patent

active

043672213

ABSTRACT:
Culturing Strepococcus agalactiae in a nutrient broth containing at least 10 g/l of glucose while maintaining the pH at 6-8 by the addition of alkaline material produces polysaccharide antigen including a fraction having a molecular size from 8-11.times.10.sup.5 d. By employing a broth free from constituents having a molecular size above 10.sup.5, the antigens can be separated from the broth in high yield after harvesting the organisms. Vaccination of humans with Streptococcus agalactiae polysaccharide antigens having molecular sizes above 5.times.10.sup.5 produces in selected individuals specific antibody levels above 200 .mu.g/ml of antisera; globulins fractionated from such antisera contain most of the antibody and can be used for passive immunization.

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