Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Fusion protein or fusion polypeptide
Reexamination Certificate
2006-06-13
2006-06-13
Housel, James C. (Department: 1648)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Fusion protein or fusion polypeptide
C424S186100, C424S218100
Reexamination Certificate
active
07060280
ABSTRACT:
A method of inducing an immune response in a subject against a flavivirus. The method involves administering to the subject with a fusion polypeptide including a signal peptide and a part of an envelope protein of the flavivirus, or with an expression vector containing a nucleic acid encoding the fusion polypeptide. Also disclosed are a polypeptide, an expression vector, and vaccines containing the polypeptide or expression vector.
REFERENCES:
patent: 6455509 (2002-09-01), Kochel et al.
patent: 2003/0022849 (2003-01-01), Chang
patent: WO 200020565 (2000-04-01), None
Yasui, K, et al., Analysis of Japanese Encephalitis (JE) Virus Genome and Implications for Recombinant JE Vaccine (1990) Southeast Asian J Trop Med Public Health, vol. 21, No. 4, pp. 663-669.
Ashok and Rangarajan, Protective efficacy of a plasmid DNA encoding Japanese encephilitis virus envelope protein fused to tissue plasminogen activator signal sequences: studies in a murine intacerebral virus . . . (Feb. 2002) Vaccine vol. 20 pp. 1563-1570.
Ashok and Rangarajan (2000) Vaccine, vol. 18 pp. 68-75.
Hsin-Wei Chen et al. “Screening of Protective Antigens of Japanese Encephalitis Virus by DNA Immunization: a Comparative Study with Conventional Viral Vaccines”. Journal of Virology, 73(12):10137-10145, Dec. 1999.
Shwn-Chin Chia et al. “Fragment of Japanese encephalitis virus envelope protein produced inEscherichia coliprotects mice from virus challenge”. Microbial Pathogenesis 31:9-19, 2001.
D. Haddad et al. “Characterization of Antibody Responses to aPlasmodium falciparumBlood-Stage Antigen Induced by a DNA Prime/Protein Boost Immunization Protocol”. Scand. J. Immunol. 49:506-514, 1999.
Eui Konishi et al. “A Highly Attenuated Host Range-Restricted Vaccinia Virus Strain, NYVAC, Encoding the prM, E, and MS1 Genes of Japanese Encephalitis Virus Prevents JEV Viremia in Swine”. Virology 190:454-458, 1992.
Eui Konishi et al. “A vipox virus-vectored Japanese encephalitis virus vaccines: use as vaccine candidates in combination with purified subunit immunogens”. Vaccine 12(7):633-638, 1994.
Eui Konishi et al. “Comparison of Protective Immunity Elicited by Recombinant Vaccinia Viruses That Synthesize E or NS1 of Japanese Encephalitis Virus”. Virology 185:401-410, 1991.
Chien-Hsiung Pan et al. “Protective Mechanisms Induced by a Japanese Encephalitis Virus DNA Vaccine: Requirement for Antibody but Not CD8+ Cytotoxic T-Cell Responses”. Journal of Virology 75(23):11457-11463, Dec. 2001.
J. F. L. Richmond et al. “Studies of the Neutralizing Activity and Avidity of Anti-Human Immunodeficiency Virus Type 1 Env Antibody Elicited by DNA Priming and Protein Boosting”. Journal of Virology 72(11):9092-9100, Nov. 1998.
Jeong-Im Sin et al: “DNA Priming-Protein Boosting-Enhances Both Antigen-Specific Antibody and Th1-Type Cellular Immune Responses in a Murine Herpes Simplex Virus-2 gD Vaccine Model”. DNA and Cell Biology 18(10):771-779, 1999.
Man Ki Song et al. “Enhancement of Immunoglobulin G2a and Cytotoxic T-Lymphocyte Responses by a Booster Immunization with Recombinant Hepatitis C Virus E2 Protein in E2 DNA-Primed Mice”. Journal of Virology 74(6):2920-2925, Mar. 2000.
Academia Sinica
Fish & Richardson P.C.
Housel James C.
Salvoza M. Franco
LandOfFree
Immunization against flavivirus does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Immunization against flavivirus, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Immunization against flavivirus will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3617246