Drug – bio-affecting and body treating compositions – Lymphokine
Patent
1991-03-01
1993-05-11
Nucker, Christine M.
Drug, bio-affecting and body treating compositions
Lymphokine
514 2, 514 8, 530350, 530395, 530806, 530820, A61K 39018
Patent
active
052099296
ABSTRACT:
Antigenic surface proteins from the intraerythrocytic merozoite stage of Babesia bigemina have been isolated using cell fusions and monoclonal antibodies produced thereby. Immunization of mammals, such as bovines, with purified isolates induces an immunological response that is effective to reduce pathological effects of babesiosis induced by Babesia bigemina. Diagnostic kits using monoclonal antibodies and antigenic surface proteins of Babesia bigemina are also disclosed.
REFERENCES:
patent: 4661348 (1987-04-01), Wright
I. G. Wright, et al. Jul. 1983, Infect. Immun. 41:244-50. "B. bovis: Isolation of a Protective Antigen by Using MAbs".
Braude, A. I. et al., (eds). 1986 Infectious Diseases and Medical Microbiology. pp. 620-621, 1265-1269.
T. F. McElwain, et al. Apr., 1987, J. Immunol. 138(7): 2298-2304. "Antibodies Define Multiple Proteins with Epitopes Exposed on the Surface of Live B. babesis Merozoites".
I. G. Wright et al. Feb. 1987. Infect. Immun. 55(2): 364-368, "Protection of Babesis bigemins-Immune Animals Against Subsequent Challenge with Virulent Babesis bovis".
Davis William
McElwain Terry
McGuire Travis
Perryman Lance
Cunningham T.
Nucker Christine M.
Washington State University Research Foundation
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