Drug – bio-affecting and body treating compositions – Extract – body fluid – or cellular material of undetermined... – Milk or colostrum
Patent
1995-06-02
1999-01-26
Scheiner, Laurie
Drug, bio-affecting and body treating compositions
Extract, body fluid, or cellular material of undetermined...
Milk or colostrum
4241841, 4241931, 4242781, 424520, 530832, 530868, A61K 3520
Patent
active
058635610
ABSTRACT:
An immune suppressive product prepared by injecting an allergen or a mixture of allergens into the body of milk-producing species. Said product being the milk or a polypeptide subfraction of milk obtained from the allergen treated host. The immune suppressive product(s) is milk and or the polypeptide fractions contained therein, which is ostensively free of the intact allergen or allergens used for the treatment of the host. The immune suppressive factor(s) being a subfraction of the allergen used for the treatment. A method of preparing immune suppressive polypeptides from intact allergens, which involves injection of the specific intact allergens into a milk-producing species, collecting the immune suppressive polypeptide fractions of the intact allergens from the milk of the treated host. The immune suppressive milk containing said polypeptide fractions, and/or the polypeptide fractions obtained from said milk, are nonreactive in animals and humans as allergens. Said factor(s), however, are highly effective in preventing or alleviating allergic reactions.
REFERENCES:
patent: Re33403 (1990-10-01), Stolle et al.
patent: 4284623 (1981-08-01), Beck
patent: 4469677 (1984-09-01), Michael et al.
patent: 4636384 (1987-01-01), Stolle et al.
patent: 4732757 (1988-03-01), Stolle et al.
patent: 4879110 (1989-11-01), Beck et al.
patent: 4956349 (1990-09-01), Beck
patent: 5130128 (1992-07-01), Stolle
Hanson, D.G. et al., Inhibition of Specific Immune Response By Feeding Protein Antigens, Int. Archs. Allergy Appl. Immun. 55:526-532 (1977).
Higgins, P.J. et al., Suppression of Experimental Autoimmune Encephalomyelitis By Oral Administration Of Myelin Basic Protein And Its Fragments, J. Immunol. 140:440-445 (1988).
Lafont, S. et al., Abrogation By Subsequent Feeding Of Antibody Response, Including IgE In Parenterally Immunized Mice, J. Exp. Med. 155:1573-1578 (1982).
Liu, Fu-Tong et al., Immunological Tolerance To Allergenic Protein Determinants: A Therapeutic Approach For Selective Inhibition of IgE Antibody Production, Proc. Nat'l Acad. Sci., U.S.A., 76:1430-1434 (1979).
Mowat, A. McI., The Role of Antigen Recognition And Suppressor Cells In Mice With Oral Tolerance To Ovalbumin, Immunology 56:253-260 (1985).
Nagler-Anderson, C. et al., Suppression of Type II Collagen-Induced Arthritis By Intragastric Administration Of Soluble Type II Collagen, Proc. Nat'l. Acad. Sci. 83:7443-7446 (1986).
Patterson, R., Allergen Immunotherapy With Modified Allergens, J. Allergy Clin. Immunol. 68:85-90 (1981).
Supplementary Partial European Search Report for Application No. EP 91/909 691 (Jun. 1, 1993).
Beck Lee R.
Stolle Ralph J.
Scheiner Laurie
Stolle Research & Development Corporation
LandOfFree
Immune suppressive product does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Immune suppressive product, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Immune suppressive product will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1448237