Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Method of regulating cell metabolism or physiology
Patent
1996-09-11
1998-03-03
Rories, Charles C.P.
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Method of regulating cell metabolism or physiology
514 44, 424 173, 424 177, 4242801, 536 231, 536 243, 536 2431, 536 2433, C12N 510, A61K 3170, A61K 31795, C07H 2100
Patent
active
057233357
ABSTRACT:
Methods of stimulating a local immune response in selected cells or tissues employing immunopotentiating oligonucleotide analogs having at least one phosphorothioate internucleotide bond are provided. Methods of enhancing the efficacy of a therapeutic treatment by stimulating a local immune response in selected cells or tissues employing oligonucleotide analogs having at least one phosphorothioate bond are also provided. The oligonucleotide analogs may have antisense efficacy in addition to immunopotentiating activity. Methods of modulating cytokine release in skin cells and immunopotentiators which include oligonucleotide analogs having at least one phosphorothioate bond capable of eliciting a local inflammatory response are also provided.
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Glover Josephine M.
Hutcherson Stephen L.
ISIS Pharmaceuticals Inc.
Rories Charles C.P.
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